Posted by Cody Lyles on Oct 03, 2025
In today’s research landscape, accurate, repeatable, and ethical body composition analysis is essential. Whether you’re working in preclinical studies, metabolic research, toxicology, nutrition, or drug development, understanding changes in fat, lean tissue, and body water is critical to advancing knowledge and improving outcomes.
The Bruker minispec LF Series, distributed by Rotunda SciTech, is a trusted line of TD-NMR (Time-Domain Nuclear Magnetic Resonance) instruments designed to deliver fast, non-invasive, and stress-free body composition measurements. , allowing you to combines scientific rigor with user-friendly workflows that make it a top choice for laboratories worldwide.
Traditional approaches often rely on anesthesia, invasive procedures, or even sacrificing animals, resulting in stressed animals and higher costs. The minispec LF Series enables measurements on awake animals, eliminating recovery time and ensuring animal welfare is preserved.
Because animals can be measured daily without sacrifice, researchers can track body composition over the entire lifespan of each study subject. This makes the minispec LF Series invaluable for long-term studies in obesity, aging, and disease models.
With its unique probe-in-probe design, the system delivers high sensitivity and accuracy (~1% of total mass) even for small biopsies or newborn mice. This ensures your data is robust, reproducible, and accurate, preparing you to meet scientific and regulatory requirements.
The integrated software guides users step-by-step, requiring no prior NMR expertise. The LF Series provides results in as little as two minutes with no preparation, making body composition measurements accessible and efficient for any research team.
Preclinical research: monitor body composition in small animals to study drug effects or disease progression.
Metabolism and nutrition studies: track changes in fat vs. lean mass under different diets or interventions.
Aging and longevity research: evaluate body composition shifts throughout an animal’s life.
Toxicology and pharmacology: detect unintended changes in lean/fat balance as part of safety assessments.
Non-destructive sample analysis: measure organ and tissue samples, biopsies, animal feed, and feces without damaging specimens.
The minispec LF Series is available in three configurations, each tailored to specific research needs:
🔹 minispec LF50 – For mice up to 60 g🔹 minispec LF90II – For rats up to 700 g; dual-probe system also suited for mice, organs, and biopsies🔹 minispec LF110 – For heavier rats (up to 1 kg), with the same dual-probe versatility as LF90II
Non-Invasive & Stress-Free: Measure animals while awake with patented red restrainers designed to minimize handling stress
Fast Results: Full body composition analysis in under 2 minutes
High Precision: Accuracy within ~1% of total mass
Repeatable Data: Daily measurements enable longitudinal tracking
Measurement frequency: 7.5 MHz (LF50), 6.2 MHz (LF90II), 5.7 MHz (LF110)
Sample weight range: 50 mg biopsies to 1 kg rats
Microsoft Windows + Access-based data management
ISO 9001 certified | CE conforming
The Bruker minispec LF Series is more than just an instrument—it’s a solution that brings precision, comfort, and efficiency to animal research. By combining non-invasive methods, rapid turnaround, and longitudinal study capability, it empowers researchers to generate high-quality data while improving animal welfare and experimental efficiency.
Whether you’re focused on metabolism, nutrition, aging, toxicology, or preclinical pharmacology, the minispec LF Series delivers the accuracy and usability your lab needs.
Explore the full details of the minispec LF Series on the official Rotunda Scientific Technologies product page.
Rotunda SciTech – minispec LF Series Product Page. https://www.rotundascitech.com/products/minispec-lf-series
Bruker – minispec LF Series: Body Composition Analyzers. https://www.bruker.com/en/products-and-solutions/mr/nmr-clinical-research-solutions/minispec-lf-series.html
Syntech Innovation – minispec LF110 Datasheet (PDF). https://syntechinnovation.com/images/catalog/advance-analytical/4NMR/minispec_LF110_T137087.pdf
This article was written in part with the assistance of AI to help organize, summarize, and reference publicly available information.
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